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Coating Polymers

“TITANCOAT”
Enhancing Better drug delivery

The effectiveness of a drug depends not only on the active used but also on the coating done. Herewith we introduce TITAN PHARMA’s coating polymers as TITANCOAT one of the finest coating product equivalents to any international brands. These polymers are described in international Pharmacopeias like Ph Eur & USP/NF.

TITANCOAT coating products are used in various application such as Film coating, tablet coating, enteric coating & sustained release etc.

TITANCOAT is your ideal partner for enchasing better drug delivery and reducing product cost.

Advantage of TITAN coating materials is as follows:

  • Increased efficiency of active drug and self-life of the product.
  • Ph dependent release
  • Keeping intact the active drug properties against moisture, light and air – coatings stable under tropical conditions
  • Resistance to gastric juice
  • Achieving  the desired release
  • Cost effective to the patient and helping them to reduce the doses taken.
  • Insulates Hygroscopic Cores
  • Isolate porous cores
  • Enhance aesthetic appeal and brand image

TITANCOAT Range of products are below

 TITANCOAT
Grades

Physical form

 Polymer Content

Properties

Application

 Pharmacopeial monograph

TITANCOAT-L 100

Powder

95%

Soluble from pH 6.0

Enteric Coating
(Solvent base)

“Methacrylic Acid Copolymer,
Type A”  USP/NF

TITANCOAT-S 100

Powder

95%

Soluble from pH 7.0

Enteric Coating
(Solvent base),
Sustained Release

“Methacrylic Acid Copolymer,
Type B”  USP/NF

TITANCOAT-L 100 55

Powder

95%

Soluble from pH 5.5

Enteric Coating
(Aqueous Base)

“Methacrylic Acid Copolymer,
Type C”  USP/NF

TITANCOAT-L 30 D

Aqueous Dispersion

30%

Soluble from pH 5.5

Enteric Coating
(Aqueous Base)

“Methacrylic Acid Copolymer Dispersion” USP/NF

TITANCOAT-NE 30 D

Aqueous Dispersion

30%

pH- Independent
easily permeable

Sustained Release
(Aqueous Base)

“Aqueous Acrylic
Polymer Dispersion” BP

TITANCOAT-L 30 D
Aqueous Dispersion
30%
Soluble from pH 5.5
Enteric Coating
(Aqueous Base)
“Methacrylic Acid Copolymer Dispersion” USP/NF

TITANCOAT-EPO

Powder

98%

Gastro Soluble up to pH 5.0

Film Coating
(Solvent Base),
Taste Masking,
Moisture Barrier

“Basic Butylated Methacrylate copolymer” Eur. Ph.

TITANCOAT-L 12.5

Organic Solution in Isopropyl Alcohol

12.5%

Soluble from pH 6.0

Enteric Coating
(Solvent Base)

“Methacrylic  Acid Copolymer,
Type A” USP/NF

 

TITANCOAT-L 100
"Methacrylic Acid Copolymer,Type A" USP/NF

DESCRIPTION

TITANCOAT - L 100 is an anionic copolymer based on methacrylic acid and methyl methacrylate. The copolymer corresponds to USP/NF "Methacrylic Acid copolymer. Type A". It is insoluble in acids and pure water. It becomes soluble in a neutral to weakly alkaline milieu by forming salts with alkalis, thus affording enteric film coatings which are soluble in intestinal juice.

CHARACTERISTICS
TITANCOAT - L 100 films are colorless and transparent, and made somewhat less brittle by the plasticizer contained therein. They are insoluble in water, in buffer solutions below pH 5.0, and also in natural and artificial gastric juices. They are soluble in the region of the digestive tract where the juices are neutral to weakly alkaline and in buffer solutions above pH 6.0.

APPLICATIONS:
Coating of pellets, granules, powders:
Coating of tablets and pills: (Colorless and transparent; colored with pigments)

  • For resistance to gastric juice
  • For resistance to gastric juice with delayed drug release in the intestines when mixed with TITANCOAT-S 100
  • For isolation of incompatible ingredients
  • To improve the keeping properties protection against moisture, light and air-coatings stable under tropical conditions
  • To insulate hygroscopic cores
  • To isolate porous cores
  • For the production of film coatings for lozenges and troches

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TITANCOAT - S 100
“Methacrylic Acid Copolymer, Type B” USP/NF

Description
TITANCOAT-S 100 is an anionic copolymer based on methacrylic acid and methyl methacrylate. The copolymer corresponds to USP/NF "Methacrylic Acid copolymer. Type B"
It is insoluble in acids and pure water. It becomes soluble in a neutral to weakly alkaline milieu by forming salts with alkalis, thus affording enteric film coatings which are soluble in intestinal juice.

Characteristics
TITANCOAT - S 100 films are colorless and transparent, and made somewhat less brittle by the addition of a plasticizer. They are insoluble in water, in buffer solutions below pH 6.0, and also in natural and artificial gastric juices. They are soluble in the region of the digestive track where the juice is neutral to weakly alkaline and in buffer solutions above pH 7.0.

Applications
Coating of tablets and pills (Colorless and transparent: colored with pigments)
Coating of pellets, granules, powders

 

  • To improve the keeping properties protection against moisture, light and air-coatings stable under tropical conditions
  • For resistance to gastric juice with delayed drug release in the intestines (from pH 7.0 upwards)
  • For resistance to gastric juice with delayed drug release in the intestines when mixed with TITANCOAT - L 100 (range : pH 6.0 - 7.0)
  • To insulate hygroscopic cores
  • To isolate porous cores
  • For the production of film coating for lozenges and troches
For isolation of incompatible ingredients

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TITANCOAT L 100-55
"Methacrylic Acid Copolymer,Type C" USP/NF

Description
TITANCOAT L 100-55 is an anionic copolymer based on methacrylic acid and ethyl acrylate. It is insoluble in acids and pure water. The polymer corresponds to USP/NF "Methacrylic Acid Copolymer, Type C".
It becomes soluble in a neutral to weakly alkaline milieu by forming salts with alkalis, thus affording film coatings which are resistant to gastric juice but freely soluble in intestinal juice

Characteristics
TITANCOAT L100-55 films are colorless and transparent; their brittleness is reduced by the addition of plasticizers. They are insoluble in water, in buffer solution below pH 5.0 and also in natural and artificial gastric juices. They are soluble in the region of the digestive tract where the juices are neutral to weakly alkaline and in buffer solutions above pH 5.5.

Possible Applications*
Coating of tablets and pills: [colorless and transparent; coloured with pigments]
Coating of Capsules & Coating of pellets, granules, powders:

 

  • To improve the keeping properties protection against moisture, light and air - coatings stable under tropical conditions
  • for resistance to gastric juice
  • for resistance to gastric juice with delayed drug release in the intestine when mixed with TITANCOAT L 100 or S 100
  • to insulate hygroscopic cores
  • to isolate porous cores
  • for the production of film coatings for lozenges and troches
  • for protection against atmospheric influences
for isolation of incompatible ingredients

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TITANCOAT NE 30D
Aqueous Acrylic Polymer Dispersion (Polyacrylate Dispersion 30%)
for controlled - release permeable film coating

Description

TITANCOAT NE 30D is the aqueous dispersion of a neutral copolymer based on ethyl acrylate.It is an aqueous dispersion containing 30% dry substance.

Characteristics of the Film

Lacquer films made from TITANCOAT NE 30D are colorless, transparent, elastic and resistant to braking. They are swellable and permeable in water, buffer solutions and digestive fluids. TITANCOAT NE 30D lacquer films are permeable to water and active substances; this means that the release of active substance via diffusion processes can be controlled.

Auxiliaries such as talc, magnesium stearate, syloid® (micronized amorphous sillicic acid), Aerosil® and kaolin (use as separating agents and lubricants), titanium dioxide and coloured pigments (to colour the film coatings) can be added to TITANCOAT NE 30D spray suspensions.

Possible Applications

Coating of pellets granulates and powders:

  • to isolate drugs whose tolerability in the upper gastrointestinal tract is poor
  • to improve stability during storage
  • to mask unpleasant tastes.
  • to procure slow release of the active substance independently of pH in the digestive tract
  • as binder or film former to produce porous matrix tablets ("wet granulation") with slow release of the active substance
to improve compressing properties during tabletting (hardness, friability, capping).

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TITANCOAT-L 30D
"Methacrylic Acid Copolymer Dispersion" USP/NF

DESCRIPTION
TITANCOAT-L 30D is an aqueous dispersion of an anionic copolymer based on Methacrylic acid. The polymer corresponds to USP24/NF19 "Methacrylic Acid Copolymer Dispersion".
It is soluble in a neutral to weakly alkaline milieu by forming salts with alkalis, thus affording ENTERIC film coating which are soluble in intestinal juice.

Characteristics of the Film
Colourless and transparent films are formed from TITANCOAT-L 30D when plasticizers (polyethylene glycol, propylene glycol, triacetin, etc.) are present. These films are insoluble below pH 5.0, and also in natural and artificial gastric juices. They are soluble in the neutral to weakly alkaline region of the digestive tract, i.e. in the intestines, in pancreatic or intestinal juice, and in buffer solutions above pH 5.5

Possible Applications

Coating of tablets and pills (Colorless and transparent: colored with pigments)
Coating of pellets, granules, powders

  • For resistance to gastric juice with delayed drug release in the intestine when thicker layers are applied.
  • To isolate porous cores.
  • For the production of film coatings for lozenges and troches.
  • For special purpose the dispersion can also be mixed with water-miscible organic solvents.
  • to improve self-protection against moisture, light and air coatings stable under tropical conditions
  • to improve self life Coating of pellets, granules, powders.
  • for isolation of incompatible ingredients.

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